Hepatitis E Virus Seroprevalence is Associated with Neurodegenerative Disorders in Older People with Dementia: A Case-Control StudyArticle Published on 2023-04-122023-06-11 Journal: The Journal of Infectious Diseases [Category] E형 간염, [키워드] Alzheimer hepatitis E virus neurodegenerative disorders older people Seroprevalence vascular pathology. [DOI] 10.1093/infdis/jiac268 PMC 바로가기
COVID-19 and risk of neurodegenerative disorders: A Mendelian randomization study Research Published on 2022-07-142022-10-05 Journal: Translational Psychiatry [Category] Coronavirus, 바이오마커, 유전자 메커니즘, [키워드] alleviate Alzheimer’s disease Analysis association complications of COVID-19 conducted correlation COVID-19 Dementia demonstrated Evidence frontotemporal dementia Future Genetic Genome-wide association study higher risk Hospitalization Lewy body mendelian randomization multiple sclerosis neurodegenerative neurodegenerative disorder neurodegenerative disorders Parkinson’s disease positive risk robust Sensitivity analyses severity severity of COVID-19 significantly suggested susceptibility therapeutic intervention [DOI] 10.1038/s41398-022-02052-3 [Article Type] Research
Identification of novel regulatory pathways across normal human bronchial epithelial cell lines (NHBEs) and peripheral blood mononuclear cell lines (PBMCs) in COVID-19 patients using transcriptome analysisResearch article Published on 2022-06-022022-10-05 Journal: Informatics in Medicine Unlocked [Category] 변종, 신약개발, [키워드] affected Analysis analysis approaches association cell line cell lines changes in conducted contribute Coronaviruses COVID COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients Differential gene expression Drug repurposing enrichment analysis epithelial epithelial cell line exacerbated Factor Gene regulatory networks help identification identify immune system Interaction interactions Lungs mononuclear cell Mutation neurodegenerative disorders NHBE organ pathway Pathway analysis PBMC PBMCs Peripheral blood regulatory network regulatory pathway SARS-CoV-2 significant pathway Streamline Support targets the disease the SARS-CoV-2 therapeutic approach Transcriptome viral replication viral strain virus [DOI] 10.1016/j.imu.2022.100979 [Article Type] Research article
Serum glial fibrillary acidic protein is a body fluid biomarker: A valuable prognostic for neurological disease – A systematic reviewReview article Published on 2022-06-012022-10-05 Journal: International immunopharmacology [Category] 바이오마커, [키워드] Acidic Alzheimer’s disease applied articles association Asthma Astrocyte Ataxia Autism spectrum disorders Biomarker Biomarkers Blood bloodstream Cell Central nervous system COVID-19 database depressive described detect Diabetic diagnostic disintegration disorder early diagnosis elevated exclusion criteria facilitate GFAp Glioblastoma initial search Intermediate filament lobar multiple sclerosis neurodegeneration neurodegenerative disorders Neurological disease Neurological diseases Neurological disorder Neurological disorders neuronal Parkinson disease prognostic Protein Regulation reported Schizophrenia Seizures Serum level Spinal cord injury stroke systematic review the disease tissue Web of Science Wilson [DOI] 10.1016/j.intimp.2022.108624 [Article Type] Review article
Implication of COVID-19 on Erythrocytes Functionality: Red Blood Cell Biochemical Implications and Morpho-Functional Aspects적혈구 기능에 대한 COVID-19의 의미: 적혈구 생화학적 의미 및 형태-기능적 측면Review Published on 2022-02-162022-09-10 Journal: International Journal of Molecular Sciences [Category] MERS, 치료제, [키워드] Affect alteration Anemia antioxidant aspect Blood blood cell Blood cells Cancer cause causes Cell change changes changes in Concentration Course COVID COVID-19 COVID-19 severity diabetes disease disease severity distribution enzyme erythrocyte erythrocytes evaluated focus help hematological hematological changes hematology hemoglobin increase in infections information Long Lower management metabolism morphology neurodegenerative disorders oxidative stress patients with COVID-19 Prevent progressed progression promote Red red blood cells reported rigidity risk SARS-CoV-2 severe COVID-19 shown the disease Viral viral infection worsening [DOI] 10.3390/ijms23042171 PMC 바로가기 [Article Type] Review
The roles of Eph receptors, neuropilin-1, P2X7, and CD147 in COVID-19-associated neurodegenerative diseases: inflammasome and JaK inhibitors as potential promising therapiesCOVID-19 관련 신경퇴행성 질환에서 Eph 수용체, 뉴로필린-1, P2X7 및 CD147의 역할: 잠재적으로 유망한 치료법으로서 인플라마솜 및 JaK 억제제Review Published on 2022-02-022022-09-10 Journal: Cellular & Molecular Biology Letters [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 치료제, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alzheimer’s disease angiotensin Angiotensin-converting enzyme antiviral drug antiviral drugs CD147 Central nervous system CNS conditions coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Critical cytokine Cytokines demonstrated Diseases effective entry receptor entry route Ephrin explain expression help host cells Inflammasome inhibitor Interaction Invasion involved Jak Ligand mechanisms neurodegenerative Neurodegenerative diseases neurodegenerative disorder neurodegenerative disorders neuropilin neuropilin 1 Neuropilin-1 Novel coronavirus novel coronavirus disease novel vaccines P2X7 pandemic Parkinson’s disease Pathogenesis pathological mechanism Protein provide receptor receptors respiratory Safe SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Spread therapeutic strategy therapy Vaccine Vaccines with COVID-19 [DOI] 10.1186/s11658-022-00311-1 PMC 바로가기 [Article Type] Review
Gut power: Modulation of human amyloid formation by amyloidogenic proteins in the gastrointestinal tractReview article Published on 2022-02-012022-10-05 Journal: Current opinion in structural biology [Category] 비임상, [키워드] alpha-synuclein Brain cell death cross-reactivity disease expressed fiber Functional amyloids gastrointestinal tract Gut initial interactions mechanism Microbiome microbiota modulate neurodegenerative disorders occur Parkinson's Disease Protein secreted [DOI] 10.1016/j.sbi.2021.07.009 [Article Type] Review article
The potential role of COVID-19 in the induction of DNA damageDNA 손상 유도에서 COVID-19의 잠재적 역할Review Published on 2022-01-012022-09-11 Journal: Mutation research. Reviews in mutation research [Category] SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 affecting appearance Atherosclerosis Brain Cancer caused Cell cell cycle chronic disease Chronic diseases coronavirus coronavirus disease Coronavirus-2 Coronaviruses COVID-19 Cytokine storm syndrome death deregulation diabetes direct viral infection DNA DNA damage DNA repair DNA repair mechanism Effect Evidence evidence of genomic Health heart immunological in some individuals induce kidney kidneys Lungs mammalian cells mechanism multiorgan failure neurodegenerative disorders organs outcome Recovered COVID-19 patients recovered patient recovered patients Replication SARS-CoV-2 SARS-CoV-2. Sepsis Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Support Symptoms these viruses viral infection virus [DOI] 10.1016/j.mrrev.2022.108411 PMC 바로가기 [Article Type] Review
Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflammationArticle Published on 2021-11-152022-10-04 Journal: Nature Communications [Category] 변종, [키워드] accelerate accompany activate activating Alzheimer's disease binding Brain cDNA Cognitive impairment disease extrinsic Genes HIV Human immunodeficiency virus in vitro in vivo induce Inflammation innate immune response Innate immunity Interaction interferon mechanism microglia microglial neurodegeneration neurodegenerative neurodegenerative disorders Neuroimmunology NFκB nuclear nuclear translocation pathway PQBP1 primary culture promote Protein receptor resulting Transcription Trigger virus infection [DOI] 10.1038/s41467-021-26851-2 PMC 바로가기 [Article Type] Article
Double stranded RNA drives anti-viral innate immune responses, sickness behavior and cognitive dysfunction dependent on dsRNA length, IFNAR1 expression and age이중 가닥 RNA는 dsRNA 길이, IFNAR1 발현 및 연령에 따라 항바이러스성 선천성 면역 반응, 질병 행동 및 인지 기능 장애를 유발합니다.Article Published on 2021-07-012022-09-11 Journal: Brain, behavior, and immunity [Category] SARS, 치료법, [키워드] age age-dependent effect age-dependent effects Alzheimer's disease Analysis Anti-viral autism base binding Brain circulating CNS cognitive Cognitive function COVID19 cytokine Cytokines dependent on disease dose dsRNA dysfunction expression Gene Expression IFN-I IFNAR1 Ifnb IFNβ IL-1β IL-6 immune activation immune responses Impact implication Inflammation innate immune response innate immune responses Innate immunity integrity IRF7 memory mice molecular weight neurodegenerative disorder neurodegenerative disorders Neuroinflammation overcome parkinson s disease Parkinson's Disease plasma Poly I:C produced Psychiatric question response responses RNA robust SARS-CoV-2 Schizophrenia Sickness Sickness behaviour significantly Symptom systemic systemic inflammation TNF-α Transcription triggered type I interferon type I interferon. viral infection viral replication Working memory [DOI] 10.1016/j.bbi.2021.04.016 PMC 바로가기 [Article Type] Article